Either way you will have to rejet. However, the 80457 will be closer to your particular jet needs. The 1850 comes jetted (basically) for a 350 Chevy. The 1850 is truely a "universal" carb, and as such will require a significant amount of tuning. also, I believe the 80457 comes with the Ford kickdown linkage. If not, there is a Holley 4160 model that comes with the linkage.
I would second the idea that the secondary metering on a 4160 is difficult to tune, especially relative to a 4150. HOWEVER, you will likely not ever need to tune it, not on a street car. Trust me, after a couple of jet changes, you'll be in the "close enough" mindset. It's no fun spilling fuel all over your intake manifold.
The constant jet changes, and an incurrable bog, led me to replace my Holley with an Edelbrock. Granted, I still have to tune the Edelbrock, but it's peanuts compared to my Holley. I still have the Holley (1850-3), if you are interested send me an email. I have it tuned much more closely to a 289 setup than stock, but it's still not quite right.