There is no use in trying to figure out the gas mileage of a prospected high horsepower engine. If you want mileage stick with a 289/302 build and keep it moderate. If you are worried about gas mileage a stroker large cubic inch engine is not for you.
Do you enjoy driving your car? Do you like to drive your car a lot? Do you plan on racing your car on a track often? If so, is track performance your main goal?
If the answer to the first two questions are yes and no to the second two then you don't need the stroker. Let's be realistic. A lot of people want to build their dream car and once they do they realize the car is almost useless on the street. This is a waste in my opinion. You simply cannot take advantage of 500HP on the street and truly enjoy it, unless just knowing it is there while you putt around getting 7 mpg is fine with you.
I always strive to build a fun, reliable, totally streetable, and enjoyable car. However fast the car is after meeting all my criteria for enjoyable useage is perfect for my needs. I never set goals on HP. I build the car for a purpose and the HP falls into the place it belongs for that purpose.
I realize a lot of people are going to disagree with me and that is fine as this is merely my opinion and formula. I am not trying to offend anyone as some people want a huge engine an that is their goal, and that is fine for them.