I , mainly, wasn't commenting on safety as such. Although it is entwined with just having beefy enough parts to handle the load. As was said above, the 6.75 is weak. They break with 6 bangers in front of them. Trying to save what? money?? sticking with the small stuff is rediculous. The 8" rears are easy enough to find. Then with the V8, you have added weight, thus the small brakes weren't designed for this new load.
As was mentioned above, rbohm is on the six cylinder site all the time. He knows his sixes and the problems that go with building more powerful engines. Just dropping in, even a stock V8 will put you were the six guys strive hard to reach. It just doesn't make any sense and hoping the OP understands this.
On another note, it was mentioned about the Maverick rears with 4 lug axles and 8" gears. The Pinto also used these rears, with V6 cars. These rears are exactly the right size for early Mustangs too. So you could use the 4 lug axles, or replace them with 5 lug. Either way these Pintos are a prime place to look as well . . . V6 cars.